0000000001311017

AUTHOR

Yiu Fung Mui

showing 2 related works from this author

Titanocene–gold complexes containing N-heterocyclic carbene ligands inhibit growth of prostate, renal, and colon cancers in vitro

2016

We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = −OC(O)-p-C6H4-S−) bound to gold(I)−N-heterocyclic carbene fragments through the thiolate group: [(η5 -C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold−N-heterocyclic carbene precursors [(NHC)Au(mbaH)] have been evaluated against renal, prostate, colon, and breast cancer cell lines. The highest activity and selectivity and a synergistic effect of the resulting heterometallic species was found for the prostate and colon cancer cell lines. The colocalization of both tita…

010405 organic chemistryLigandStereochemistryOrganic Chemistry010402 general chemistrymedicine.disease01 natural sciencesArticleIn vitro3. Good health0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundProstate cancermedicine.anatomical_structurechemistryProstatemedicineCarboxylatePhysical and Theoretical ChemistryQD0146SelectivityCarbeneMethyl group
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CCDC 1438894: Experimental Crystal Structure Determination

2017

Related Article: Yiu Fung Mui, Jacob Fernandez-Gallardo, Benelita T. Elie, Ahmed Gubran, Irene Maluenda, Mercedes Sanau, Oscar Navarro, Marıa Contel|2016|Organometallics|35|1218|doi:10.1021/acs.organomet.6b00051

(13-bis(246-trimethylphenyl)-13-dihydro-2H-imidazol-2-ylidene)-(4-carboxybenzene-1-thiolato)-gold(i)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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