0000000001311310
AUTHOR
Valentina Siino
showing 8 related works from this author
Impact of diet-induced obesity on the mouse brain phosphoproteome
2018
Obesity is closely associated to several diseases such as type 2 diabetes, cardiovascular disease, hepatic steatosis, airway disease, neurodegeneration, biliary diseases and certain cancers. It is, therefore, of importance to assess the role of nutrition in disease prevention as well as its effect in the course of such pathologies. In the present study, we addressed the impact of the exposure to different obesogenic diets in the mice brains phosphoproteome. To analyze if the obesity could be able to modify the protein pattern expression of brain neurons, obesity was induced in two different groups of mice. One group of mice was fed with hyperglycemic diet (HGD) and the other one was fed wit…
Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long‐lived individuals
2022
The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represen…
The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs)
2020
Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing. Thus, in order to gain insight into the pathophysiology of ageing and to identify new markers of longevity, we analysed the activity levels of MMP-2 and MMP-9 in association with some relevant haematochemical parameters in a Sicilian population, including long-living individuals (LLIs, ≥95 years old). A cohort of 154 healthy subjects (72 men and 82 women) of different ages (age range 20-112) was recruited. The cohort was divided into five subgroups: the first group with subjects less than…
Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains
2021
Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. As an example, in post-mortem brain of patients with Alzheimer’s disease (AD), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the AD patient’s …
sj-docx-1-nmi-10.1177_11786388211012405 – Supplemental material for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modi…
2021
Supplemental material, sj-docx-1-nmi-10.1177_11786388211012405 for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains by Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia è, Giulia Accardi and Martin Røssel Larsen in Nutrition and Metabolic Insights
sj-docx-1-nmi-10.1177_11786388211012405 – Supplemental material for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modi…
2021
Supplemental material, sj-docx-1-nmi-10.1177_11786388211012405 for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains by Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia è, Giulia Accardi and Martin Røssel Larsen in Nutrition and Metabolic Insights
sj-xlsx-2-nmi-10.1177_11786388211012405 – Supplemental material for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modi…
2021
Supplemental material, sj-xlsx-2-nmi-10.1177_11786388211012405 for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains by Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia è, Giulia Accardi and Martin Røssel Larsen in Nutrition and Metabolic Insights
sj-xlsx-3-nmi-10.1177_11786388211012405 – Supplemental material for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modi…
2021
Supplemental material, sj-xlsx-3-nmi-10.1177_11786388211012405 for Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains by Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia è, Giulia Accardi and Martin Røssel Larsen in Nutrition and Metabolic Insights