0000000001311494
AUTHOR
Abdesselam Baouid
Efficient and simple synthesis of novel 1,2,3-triazolyl-linked benzimidazolone, molecular docking and evaluation of their antimicrobial activity
In this study, a novel series of 1,2,3-triazolyl-benzimidazolone derivatives have been synthesized by click reaction of azides with benzimidazolones 2a–b. The latter compounds were prepared with excellent yields (85–97%), the structures of products were determined by spectral analysis. Then, the X-rays crystallographic analysis of compound 7a revealed the self-assembling properties. The new heterocycles were evaluated for their in vitro antimicrobial activities against Gram-positive and Gram-negative bacteria and against fungi strains. The most tested synthesized compounds showed potent antibacterial and antifungal activities against all tested strains. The compound 6c was found to be the m…
CCDC 1820200: Experimental Crystal Structure Determination
Related Article: Adardour Mohamed, Elena Zaballos-García, Loughzail Mohamed, Slimane Dahaoui, Abdesselam Baouid|2018|J.Mol.Struct.|1165|153|doi:10.1016/j.molstruc.2018.03.128