0000000001311586
AUTHOR
Rainer Misgeld
Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents
Naphthalimide-based N-heterocyclic carbene (NHC) complexes of the type [(1,5-cyclooctadiene)(NHC)RhCl)] (4 a-c), [(p-cymene)(NHC)RuCl2 )] (5 a-c), and [(NHC)CuBr] (6 a-c) were synthesized and investigated as antiproliferative agents that target DNA. The cytotoxic effects were largely driven by the naphthalimide structure, which is a DNA-intercalating moiety. Regarding the metal center, the highest activities were observed with the rhodium complexes, and cytotoxic activity was significantly lower for the ruthenium derivatives. The stable coordination of the NHC ligands of selected complexes 4 b and 5 b in solution was confirmed, and their DNA binding properties were studied by UV/Vis spectro…
CCDC 1510249: Experimental Crystal Structure Determination
Related Article: Wojciech Streciwilk, Alessio Terenzi, Rainer Misgeld, Corazon Frias, Peter G. Jones, Habil. Aram Prokop, Bernhard K. Keppler, Ingo Ott|2017|ChemMedChem|12|214|doi:10.1002/cmdc.201600557