0000000001311728

AUTHOR

E. Liepinsh

showing 8 related works from this author

Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine‐N‐oxide

2018

Aims Trimethylamine-N-oxide (TMAO) is a novel cardiovascular risk marker. We explored the association of commonly used cardiovascular medications with TMAO levels in patients and validated the identified associations in mice. Methods Detailed history of drug treatment was recorded in 300 patients with cardiovascular disease without diabetes in an observational, cross-sectional study. Animal study was performed in CD1 mice. Results Median plasma TMAO (interquartile range) level was 2.144 (1.570-3.104) μmol l-1 . Among nine cardiovascular drug groups, the use of loop diuretics (0.510 ± 0.296 in users vs. 0.336 ± 0.272 in nonusers, P = 0.008) and mineralocorticoid receptor antagonists (0.482 ±…

0301 basic medicineMalemedicine.medical_specialtyOrganic anion transporter 1medicine.drug_classTrimethylamine N-oxide030204 cardiovascular system & hematologyKidneyExcretion03 medical and health scienceschemistry.chemical_compoundMethylaminesMice0302 clinical medicineSodium Potassium Chloride Symporter InhibitorsInternal medicineBlood plasmamedicineAnimalsHumansPharmacology (medical)AgedPharmacologybiologyChemistryArea under the curveFurosemideCardiovascular AgentsHeartOriginal ArticlesLoop diureticMiddle AgedProbenecid030104 developmental biologyEndocrinologyCross-Sectional StudiesLiverCardiovascular Diseasesbiology.proteinFemaleBiomarkersmedicine.drug
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CCDC 886199: Experimental Crystal Structure Determination

2013

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

Space GroupCrystallographyMethyl 3-acetyl-5-cyano-26-dimethyl-14-dihydropyridine-4-carboxylateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 676989: Experimental Crystal Structure Determination

2008

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters126-Trimethyl-345-trimethoxycarbonyl-14-dihydropyridineExperimental 3D Coordinates
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CCDC 886197: Experimental Crystal Structure Determination

2013

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersMethyl 3-acetyl-5-cyano-1246-tetramethyl-14-dihydropyridine-4-carboxylateExperimental 3D Coordinates
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CCDC 885313: Experimental Crystal Structure Determination

2013

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

Methyl 3-acetyl-5-cyano-126-trimethyl-14-dihydropyridine-4-carboxylateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 886816: Experimental Crystal Structure Determination

2013

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

3-Acetyl-5-cyano-26-dimethyl-14-dihydropyridine-4-carboxylic acidSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 676991: Experimental Crystal Structure Determination

2008

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1246-Tetramethyl-345-trimethoxycarbonyl-14-dihydropyridineExperimental 3D Coordinates
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CCDC 676992: Experimental Crystal Structure Determination

2008

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

126-Trimethyl-4-isopropyl-345-trimethoxycarbonyl-14-dihydropyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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