Author: E. Liepinsh

0000000001311728

AUTHOR

E. Liepinsh

Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine‐N‐oxide

Aims Trimethylamine-N-oxide (TMAO) is a novel cardiovascular risk marker. We explored the association of commonly used cardiovascular medications with TMAO levels in patients and validated the identified associations in mice. Methods Detailed history of drug treatment was recorded in 300 patients with cardiovascular disease without diabetes in an observational, cross-sectional study. Animal study was performed in CD1 mice. Results Median plasma TMAO (interquartile range) level was 2.144 (1.570-3.104) μmol l-1 . Among nine cardiovascular drug groups, the use of loop diuretics (0.510 ± 0.296 in users vs. 0.336 ± 0.272 in nonusers, P = 0.008) and mineralocorticoid receptor antagonists (0.482 ±…

research product

CCDC 886199: Experimental Crystal Structure Determination

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

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CCDC 676989: Experimental Crystal Structure Determination

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

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CCDC 886197: Experimental Crystal Structure Determination

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

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CCDC 885313: Experimental Crystal Structure Determination

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

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CCDC 886816: Experimental Crystal Structure Determination

Related Article: I.Goba,B.Turovska,S.Belyakov,E.Liepinsh|2013|Khim.Get.Soedin.,SSSR||778|

research product

CCDC 676991: Experimental Crystal Structure Determination

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

research product

CCDC 676992: Experimental Crystal Structure Determination

Related Article: I.Goba, B.Turovska, J.Stradins, I.Turovskis, E.Liepinsh, S.Belyakov|2007|Khim.Get.Soedin.,SSSR||226|

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PEPhysical Sciences and Engineering
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