0000000001311854
AUTHOR
B. Fernandez
Resonance State inH7
The existence of the $^{7}\mathrm{H}$ nuclear system was investigated via a one-proton transfer reaction with a $^{8}\mathrm{He}$ beam at $15.4\mathrm{A}\text{ }\text{ }\mathrm{MeV}$ and a $^{12}\mathrm{C}$ gas target. The experimental setup was based on the active-target MAYA which allowed a complete reconstruction of the reaction kinematics. The existence of the $^{7}\mathrm{H}$ was confirmed with the identification of seven events where the system was formed with a resonance energy of ${0.57}_{\ensuremath{-}0.21}^{+0.42}\text{ }\text{ }\mathrm{MeV}$ above the $^{3}\mathrm{H}+4n$ threshold and a resonance width of ${0.09}_{\ensuremath{-}0.06}^{+0.94}\text{ }\text{ }\mathrm{MeV}$. This stu…
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…
Production and Characterization of the $^{7}$H Resonance
Détecteur MAYA; International audience; The 7H resonance was produced via one-proton transfer reaction between a 8He beam at 15.4A MeV and a 12C gas target. The experimental setup was based on the active-target MAYA which allowed a complete reconstruction of the reaction kinematics. The characterization of the identified 7H events resulted in a resonance energy of 600 keV above the 3H+4n threshold and a resonance width of 100 keV. This study represents the first unambiguous proof of the existence of the 7H state.
CCDC 672521: Experimental Crystal Structure Determination
Related Article: S.Fustero, B.Fernandez, J.F.Sanz-Cervera, N.Mateu, S.Mosulen, R.J.Carbajo, A.Pineda-Lucena, C.R.de Arellano|2007|J.Org.Chem.|72|8716|doi:10.1021/jo701484w
CCDC 711699: Experimental Crystal Structure Determination
Related Article: S.Fustero, P.Bello, B.Fernandez, C.del Pozo, G.B.Hammond|2009|J.Org.Chem.|74|7690|doi:10.1021/jo9013436
CCDC 672520: Experimental Crystal Structure Determination
Related Article: S.Fustero, B.Fernandez, J.F.Sanz-Cervera, N.Mateu, S.Mosulen, R.J.Carbajo, A.Pineda-Lucena, C.R.de Arellano|2007|J.Org.Chem.|72|8716|doi:10.1021/jo701484w