0000000001312314
AUTHOR
Marta Martínez-alonso
Experimental and theoretical characterization of the strong effects on DNA stability caused by half-sandwich Ru(II) and Ir(III) bearing thiabendazole complexes
Abstract: The synthesis and characterization of two half-sandwich complexes of Ru(II) and Ir(III) with thiabendazole as ancillary ligand and their DNA binding ability were investigated using experimental and computational methods. 1H NMR and acid–base studies have shown that aquo-complexes are the reactive species. Kinetic studies show that both complexes bind covalently to DNA through the metal site and non covalently through the ancillary ligand. Thermal stability studies, viscosity, circular dichroism measurements and quantum chemical calculations have shown that the covalent binding causes breaking of the H-bonding between base pairs, bringing about DNA denaturation and compaction. Addi…
Strong Influence of the Ancillary Ligand over the Photodynamic Anticancer Properties of Neutral Biscyclometalated IrIII Complexes Bearing 2-Benzoazole-Phenolates
In this paper, the synthesis, comprehensive characterization and biological and photocatalytic properties of two series of neutral IrIII biscyclometalated complexes of general formula [Ir(C^N)2(N^O)], where the N^O ligands are 2‐(benzimidazolyl)phenolate‐N,O (L1, series a) and 2‐(benzothiazolyl)phenolate‐N,O (L2, series b), and the C^N ligands are 2‐(phenyl)pyridinate or its derivatives, are described,. Complexes of types a and b exhibit dissimilar photophysical and biological properties. In vitro cytotoxicity tests conclusively prove that derivatives of series a are harmless in the dark against SW480 cancer cells (colon adenocarcinoma), but express enhanced cytotoxicity versus the same cel…
Highly Stable and Efficient Light-Emitting Electrochemical Cells Based on Cationic Iridium Complexes Bearing Arylazole Ancillary Ligands.
A series of bis-cyclometalated iridium(III) complexes of general formula [Ir(ppy)2(N∧N)][PF6] (ppy− = 2-phenylpyridinate; N∧N = 2-(1H-imidazol-2-yl)pyridine (1), 2-(2-pyridyl)benzimidazole (2), 1-methyl-2-pyridin-2-yl- 1H-benzimidazole (3), 2-(4′-thiazolyl)benzimidazole (4), 1- methyl-2-(4′-thiazolyl)benzimidazole (5)) is reported, and their use as electroluminescent materials in light-emitting electrochemical cell (LEC) devices is investigated. [2][PF6] and [3][PF6] are orange emitters with intense unstructured emission around 590 nm in acetonitrile solution. [1][PF6], [4][PF6], and [5][PF6] are green weak emitters with structured emission bands peaking around 500 nm. The different photoph…
CCDC 1857871: Experimental Crystal Structure Determination
Related Article: Marta Martínez-Alonso, Natalia Busto, Larry Danilo Aguirre, Leticia Berlanga, M. Carmen Carrión, José V. Cuevas, Ana M. Rodríguez, Arancha Carbayo, Blanca R. Manzano, Enrique Ortí, Félix A. Jalón, Begoña García, Gustavo Espino|2018|Chem.-Eur.J.|24|17523|doi:10.1002/chem.201803784
CCDC 1519073: Experimental Crystal Structure Determination
Related Article: Marta Martínez-Alonso, Jesús Cerdá, Cristina Momblona, Antonio Pertegás, José M. Junquera-Hernández, Aránzazu Heras, Ana M. Rodríguez, Gustavo Espino, Henk Bolink, and Enrique Ortí|2017|Inorg.Chem.|56|10298|doi:10.1021/acs.inorgchem.7b01167
CCDC 1519074: Experimental Crystal Structure Determination
Related Article: Marta Martínez-Alonso, Jesús Cerdá, Cristina Momblona, Antonio Pertegás, José M. Junquera-Hernández, Aránzazu Heras, Ana M. Rodríguez, Gustavo Espino, Henk Bolink, and Enrique Ortí|2017|Inorg.Chem.|56|10298|doi:10.1021/acs.inorgchem.7b01167