0000000001314178

AUTHOR

Chenyin Wang

showing 2 related works from this author

Indole Diterpenoids from an Endophytic Penicillium sp.

2019

A chemical investigation of the endophyte Penicillium sp. (strain ZO-R1-1), isolated from roots of the medicinal plant Zingiber officinale, yielded nine new indole diterpenoids (1-9), together with 13 known congeners (10-22). The structures of the new compounds were elucidated by 1D and 2D NMR analysis in combination with HRESIMS data. The absolute configuration of the new natural products 1, 3, and 7 was determined using the TDDFT-ECD approach and confirmed for 1 by single-crystal X-ray determination through anomalous dispersion. The isolated compounds were tested for cytotoxicity against L5178Y, A2780, J82, and HEK-293 cell lines. Compound 1 was the most active metabolite toward L5178Y ce…

IndolesMagnetic Resonance SpectroscopyStereochemistryPharmaceutical ScienceAntineoplastic Agents01 natural sciencesEndophyteAnalytical Chemistrychemistry.chemical_compoundTermészettudományokCell Line TumorDrug DiscoveryEndophytesHumansKémiai tudományokPharmacologyIndole testOvarian NeoplasmsBiological ProductsNatural productbiology010405 organic chemistryOrganic ChemistryAbsolute configurationPenicilliumNuclear magnetic resonance spectroscopybiology.organism_classificationTerpenoid0104 chemical sciences010404 medicinal & biomolecular chemistryHEK293 CellsComplementary and alternative medicinechemistryPenicilliumMolecular MedicineFemaleDiterpenesTwo-dimensional nuclear magnetic resonance spectroscopyJournal of natural products
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CCDC 1862565: Experimental Crystal Structure Determination

2019

Related Article: Ni P. Ariantari, Elena Ancheeva, Chenyin Wang, Attila Mándi, Tim-O. Knedel, Tibor Kurtán, Chaidir Chaidir, Werner E. G. Müller, Matthias U. Kassack, Christoph Janiak, Georgios Daletos, Peter Proksch|2019|J.Nat.Prod.|82|1412|doi:10.1021/acs.jnatprod.8b00723

Space GroupCrystallographyCrystal SystemCrystal Structure2214b-trimethyl-23671314b1516-octahydro-316a-epoxyoxepino[3'2':56]naphtho[12-b]carbazol-4(5bH)-oneCell ParametersExperimental 3D Coordinates
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