0000000001314736
AUTHOR
Mao Quan
A supramolecular system that strictly follows the binding mechanism of conformational selection
Induced fit and conformational selection are two dominant binding mechanisms in biology. Although induced fit has been widely accepted by supramolecular chemists, conformational selection is rarely studied with synthetic systems. In the present research, we report a macrocyclic host whose binding mechanism is unambiguously assigned to conformational selection. The kinetic and thermodynamic aspects of this system are studied in great detail. It reveals that the kinetic equation commonly used for conformational selection is strictly followed here. In addition, two mathematical models are developed to determine the association constants of the same guest to the two host conformations. A “confo…
A 2,3-dialkoxynaphthalene-based naphthocage
A 2,3-dialkoxynaphthalene-based naphthocage has been synthesized. This naphthocage prefers to bind small organic cations with its low-symmetry conformation, which is in contrast to 2,6-dialkoxynaphthalene-based naphthocages. Self-sorting of these two naphthocages with two structurally similar guests tetramethylammonium and tetraethylammonium was achieved as well. peerReviewed
CCDC 1950443: Experimental Crystal Structure Determination
Related Article: Liu-Pan Yang, Li Zhang, Mao Quan, Jas S. Ward, Yan-Long Ma, Hang Zhou, Kari Rissanen, Wei Jiang|2020|Nat.Commun.|11|2740|doi:10.1038/s41467-020-16534-9
CCDC 1971100: Experimental Crystal Structure Determination
Related Article: Song-Bo Lu, Hongxin Chai, Jas S. Ward, Mao Quan, Jin Zhang, Kari Rissanen, Ray Luo, Liu-Pan Yang, Wei Jiang|2020|Chem.Commun.|56|888|doi:10.1039/C9CC09585C