0000000001316465

AUTHOR

Kathrine J. Vinknes

showing 12 related works from this author

Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino aci…

2021

Abstract Objective In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow + PUFA diet vs. Met/Cyshigh + SFA. Results The diet groups consisted of five women and two men, aged 20–38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol…

Male0301 basic medicinelcsh:MedicinePilot ProjectsSerinechemistry.chemical_compoundMethionine0302 clinical medicinePyruvic AcidAmino AcidsOral glucose tolerancelcsh:QH301-705.5chemistry.chemical_classificationGlucose tolerance testmedicine.diagnostic_testfood and beveragesGeneral MedicineVDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850Amino acidResearch NoteFatty Acids UnsaturatedFemalePolyunsaturated fatty acidAdultPyruvatemedicine.medical_specialty030209 endocrinology & metabolismGeneral Biochemistry Genetics and Molecular BiologyYoung Adult03 medical and health sciencesInternal medicinemedicineHumansCysteineLactic AcidFatty acidslcsh:Science (General)Oral glucose toleranceMethioninelcsh:RFatty acidGlucose Tolerance TestDietary FatsSCD030104 developmental biologyEndocrinologychemistrylcsh:Biology (General)Cysteine restrictionMethionine restrictionCysteinelcsh:Q1-390
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Sulfur amino acid restriction, energy metabolism and obesity

2021

Abstract Background Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health. Method/design Men and women (calculated sample size = 60), aged 18–45 years, with body mass index of 27–35 kg/m2 will be included in a double-blind 8-week dietary intervention study. The participants will be randomized in a 1:1 manner to a diet with either low or high SAA. Both groups will receive an equal base di…

0301 basic medicineMaleAdipose tissuePhysiologyUrineOverweightMETHIONINE RESTRICTIONchemistry.chemical_compound0302 clinical medicineProtocolMedicine030212 general & internal medicineAmino AcidsRandomized Controlled Trials as TopicRISKPLASMARGeneral MedicineMiddle AgedAmino Acids SulfurADIPOSE-TISSUEVDP::Medisinske Fag: 700::Helsefag: 800Body CompositionCYSTEINEMedicineFemaleLIFE-STYLEmedicine.symptomAdultAdolescentMetabolic healthAdipose tissueSulfur amino acidsGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesYoung AdultHumansResting energy expenditureObesityPlasma biomarkersMethioninebusiness.industryRepeated measures designTranslational researchmedicine.diseaseObesityPREVENTIONDietary intervention030104 developmental biologychemistryCysteine restrictionGene expressionbusinessEnergy MetabolismBody mass indexJournal of Translational Medicine
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Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial

2018

Dietary and plasma total cysteine (tCys) have been associated with adiposity, possibly through interaction with stearoyl&ndash

Male0301 basic medicineTaurineTaurinePilot Projectschemistry.chemical_compoundcysteineAdipositychemistry.chemical_classificationNutrition and Dieteticsbiologyfood and beveragesclinical trialAmino acidAmino Acids SulfurFatty Acids UnsaturatedCystineFemalelipids (amino acids peptides and proteins)lcsh:Nutrition. Foods and food supplyStearoyl-CoA Desaturasehormones hormone substitutes and hormone antagonistsPolyunsaturated fatty acidAdultmedicine.medical_specialtyCystinelcsh:TX341-641digestive systemArticleYoung Adult03 medical and health sciencesCystathionineInternal medicinemedicineHumansObesitymethionineamino acids030109 nutrition & dieteticsMethionineFatty acidnutritional and metabolic diseasessteaoryl-CoA desaturaseCystathionine beta synthaseDietEndocrinologychemistrybiology.proteinEnergy MetabolismFood ScienceCysteineNutrients
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Additional file 2 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 2: Contains a figure of the participant flow.

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Additional file 4 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 4: Contains descriptive statistics of the measured metabolites.

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Additional file 1 of Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary interv…

2021

Additional file 1. SPIRIT checklist 2013: Recommended items to address in clinical trial protocol and related documents*.

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Additional file 5 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 5: Contains a figure illustrating the data on pyruvate and lactate.

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Additional file 2 of Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary interv…

2021

Additional file 2. The informed consent letter (in Norwegian).

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Additional file 3 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 3: Contains baseline table of the study population.

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Additional file 1 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 1: Contains a typical daily menu and the nutrient contents of the diets.

GeneralLiterature_MISCELLANEOUShealth care economics and organizations
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Additional file 6 of Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolera…

2021

Additional file 6: CONSORT checklist.

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Additional file 3 of Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary interv…

2021

Additional file 3. Design file for power calculations.

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