Author: Jonas Rein

0000000001316513

AUTHOR

Jonas Rein

Electrochemical C−H Functionalization of (Hetero)Arenes—Optimized by DoE

Abstract A novel approach towards the activation of different arenes and purines including caffeine and theophylline is presented. The simple, safe and scalable electrochemical synthesis of 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP) aryl ethers was conducted using an easy electrolysis setup with boron‐doped diamond (BDD) electrodes. Good yields up to 59 % were achieved. Triethylamine was used as a base as it forms a highly conductive media with HFIP, making additional supporting electrolytes superfluous. The synthesis was optimized using Design of Experiment (DoE) techniques giving a detailed insight to the significance of the reaction parameters. The mechanism was investigated by cyclic volt…

research product

CCDC 1988067: Experimental Crystal Structure Determination

Related Article: Maurice Dörr, Johannes L. Röckl, Jonas Rein, Dieter Schollmeyer, Siegfried R. Waldvogel|2020|Chem.-Eur.J.|26|10195|doi:10.1002/chem.202001171

research product

PEPhysical Sciences and Engineering
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LSLife Sciences
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