0000000001316652

AUTHOR

Dace Tirzite

showing 5 related works from this author

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines

2019

The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparti…

CytotoxicityDLStoxicity on microorganismsPharmaceutical ScienceNanoparticlelcsh:RS1-44102 engineering and technologySynthetic lipids010402 general chemistry01 natural sciencesHydrophobic effectToxicity on microorganismslcsh:Pharmacy and materia medicaself-assembling propertieschemistry.chemical_compoundPhospholipid bindingAmphiphilePolymer chemistrysynthetic lipids:NATURAL SCIENCES:Physics [Research Subject Categories]pyridinium and propargyl moietiesMoietyBifunctionalAlkylSelf-assembling propertieschemistry.chemical_classification021001 nanoscience & nanotechnology3. Good health0104 chemical sciencesphospholipid bindingchemistryPropargylTEMNanoparticlescytotoxicitynanoparticlesPyridinium0210 nano-technologyPyridinium and propargyl moietiesPharmaceutics
researchProduct

Evaluation of Antiradical Activity and Reducing Capacity of Synthesised Bispyridinium Dibromides Obtained by Quaternisation of 4-Pyridyl-1,4-dihydrop…

2015

New bispyridinium dibromides based on the 1,4-dihydropyridine (1,4-DHP) cycle were synthesised in the reaction between 4-pyridyl-1,4-DHP derivatives and propargyl bromide. It has been shown that variation of the substituent position on the pyridine as well as small changes in the electronic nature of the 1,4-DHP cycle as a result of the substituent nature at the 3 and 5 positions do not affect the course of the reaction and in all cases the corresponding bispyridinium dibromides 4a–e were formed. The antiradical activity, using 1,1-diphenyl-2-picrylhydrazine as a free radical scavenger, and the reducing capacity using phosphomolybdenum complexes have been evaluated for the newly synthesise…

Green chemistrychemistry.chemical_compoundReaction mechanismchemistryBiocatalysisPyridineSubstituentSupramolecular chemistryOrganic chemistryGeneral ChemistryPropargyl bromideFree radical scavengerMedicinal chemistryAustralian Journal of Chemistry
researchProduct

Medicinal plants and their uses recorded in the Archives of Latvian Folklore from the 19th century.

2020

Abstract Ethnopharmacological relevance The records of folk medicine present historical evidence of medicinal plant usage in the territory of Latvia and describe native and imported plants and plant products that were used as medicine. Aim of the study To collect and analyse the ethnobotanical knowledge found in records of Latvian folk medicine available in the Archives of Latvian Folklore. Materials and methods Following the International Classification of Primary Care, plant uses were grouped into one of the 17 categories based on the body systems and psychological and social problems. Each plant was identified by its scientific name according to The Plant List website. Additionally, the …

Ethnobotany03 medical and health sciencesHerbal tea0302 clinical medicineDrug Discoverymedia_common.cataloged_instanceHumansEuropean unionMedicinal plantsFolklore030304 developmental biologymedia_commonPharmacology0303 health sciencesAchillea millefoliumPlants MedicinalTraditional medicineHistory 19th CenturyNative plantLatviaGeography030220 oncology & carcinogenesisEthnobotanyArtemisia absinthiumMedicine TraditionalPlant PreparationsEthnomedicineJournal of ethnopharmacology
researchProduct

Data on medicinal plants in the records of Latvian folk medicine from the 19th century

2019

Abstract The data presented in this article is in support of the research paper “Medicinal plants and their uses recorded in the Archives of Latvian Folklore from the 19th century” [1]. This article provides the list of plant species and disorders treated with medicinal plants mentioned in the records of Latvian folk medicine and used by indigenous people of Latvia in the 19th century. In total, the data include 211 genera belonging to 71 plant families. The accepted scientific names of plant species, plant parts used, dosage forms of herbal medicines, and routes of administration are reported in the table. Plant uses are grouped into one of the 17 categories based on the body systems and p…

Folk medicine0303 health sciencesMultidisciplinaryFolklorefungiRecords of Latvian folk medicineEthnobotanyLatvianfood and beveragesFolk medicinelanguage.human_languageIndigenous03 medical and health sciences0302 clinical medicineGeographyMedicinal plantsEthnobotanyBiochemistry Genetics and Molecular BiologyPlant specieslanguageEthnologyMedicinal plants030217 neurology & neurosurgery030304 developmental biologyData in Brief
researchProduct

CCDC 978170: Experimental Crystal Structure Determination

2015

Related Article: Martins Rucins, Marina Gosteva, Sergey Belyakov, Arkadij Sobolev , Karlis Pajuste, Mara Plotniece, Brigita Cekavicus, Dace Tirzite, Aiva Plotniece|2015|Aust.J.Chem.|68|86|doi:10.1071/CH14033

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters11'-prop-1-ene-23-diylbis(3-(35-bis(ethoxycarbonyl)-26-dimethyl-14-dihydropyridin-4-yl)pyridinium) dibromideExperimental 3D Coordinates
researchProduct