0000000001317424

AUTHOR

Rocco Cosimo Damiano Merolla

showing 3 related works from this author

Estimated prevalence of undiagnosed HCV infected individuals in Italy: A mathematical model by route of transmission and fibrosis progression

2021

Abstract Background The universal treatment of diagnosed patients with chronic HCV infection has been widely conducted in Italy since 2017. However, the pool of individuals diagnosed but yet to be treated in Italy has been estimated to end around 2025, leaving a significant proportion of infected individuals undiagnosed/without care. Estimates of this population are currently unknown. Methods A probabilistic modelling approach was applied to estimate annual historical HCV incident cases by their age-group (0–100 years) distribution from available literature and Italian National database (1952 to October 2019). Viraemic infection rates were modelled on the main infection routes in Italy: peo…

Liver CirrhosisPediatricsBlood transfusionEpidemiologymedicine.medical_treatmentlaw.invention0302 clinical medicineFibrosislawEpidemiologyPrevalence030212 general & internal medicineStage (cooking)ChildSubstance Abuse IntravenousMonte CarloAged 80 and overeducation.field_of_studyMiddle AgedHepatitis CInfectious DiseasesTransmission (mechanics)ItalyChild PreschoolHCVmedicine.symptomModels Theoretical: Young AdultHumanAdultmedicine.medical_specialtySexual transmissionAdolescentLiver Cirrhosi030231 tropical medicinePopulationMarkov chainAntiviral AgentsMicrobiologyAsymptomaticlcsh:Infectious and parasitic diseasesYoung Adult03 medical and health sciencesVirologymedicineHumanslcsh:RC109-216Hepatitis C infectioneducationAgedAntiviral Agentbusiness.industryPublic Health Environmental and Occupational HealthInfant NewbornUndiagnosedInfantModels Theoreticalmedicine.diseaseParasitologybusiness
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Addressing HCV Elimination Barriers in Italy: Healthcare Resource Utilization and Cost Impact Using 8 Weeks’ Glecaprevir/Pibrentasvir Therapy

2021

Introduction: In Italy, hepatitis C virus (HCV) elimination is achievable; however, barriers remain to achieving the World Health Organization's elimination targets, and have become more pronounced with the spread of COVID-19. Glecaprevir/pibrentasvir (G/P) is a direct-acting antiviral therapy for HCV, approved for 8-week treatment in patients without cirrhosis, and with compensated cirrhosis (CC). Previously, 12 weeks of therapy was recommended for patients with CC. Shortened treatment may reduce the burden on healthcare resources, allowing more patients to be treated. This study presents the benefits that 8-week vs 12-week treatment with G/P may have in Italy. Methods: A multicohort Marko…

0301 basic medicineMicrobiology (medical)medicine.medical_specialtyCoronavirus disease 2019 (COVID-19)EliminationTreatment duration030106 microbiologyPopulationTreatment duration03 medical and health sciences0302 clinical medicineHealth careTreatment duration.Medicine030212 general & internal medicineeducationOriginal ResearchHepatitis C viruseducation.field_of_studyGlecaprevir/pibrentasvirbusiness.industryGlecaprevirPibrentasvirInfectious DiseasesItalyEmergency medicineObservational studyGlecaprevir / pibrentasvirHepatitis C virubusinessInfectious Diseases and Therapy
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Addressing HCV Elimination Barriers in Italy: Health Care Resource Utilization and Cost Impact Using 8 Weeks’ Glecaprevir/Pibrentasvir Therapy

2021

Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2021.

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