0000000001317427

AUTHOR

Lorenzo Lazzari

showing 2 related works from this author

Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myelo…

2022

Post-transplant cyclophosphamide (PTCy) has emerged as a promising graft-versus-host disease (GvHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no studies have reported the efficacy of a GvHD prophylaxis based on PTCy with sirolimus (Sir-PTCy) in patients with acute myeloid leukemia (AML). In this retrospective study, we analyze the use of sirolimus in combination with PTCy, with or without mycophenolate mofetil (MMF), on 242 consecutive adult patients with AML undergoing a myeloablative first allo-HSCT from different donor types, in three European centers between January 2017 and December 2020. Seventy-seven (32%) patients received allo-HSCT from…

AdultSirolimusTransplantationBLOODTransplantation ConditioningCONDITIONING INTENSITYGVHD PROPHYLAXISHematopoietic Stem Cell TransplantationGraft vs Host Disease1ST COMPLETE REMISSIONHematologyMycophenolic AcidOPEN-LABELDIAGNOSISPatologiaHEMATOLOGIC MALIGNANCIESEUROPEAN-SOCIETYLeukemia Myeloid AcuteRISK INDEXHumansMARROW-TRANSPLANTATIONUnrelated DonorsCyclophosphamideRetrospective StudiesBone marrow transplantation
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Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myelo…

2022

Dataset used for the study "Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myeloid leukemia"

surgical procedures operativehemic and lymphatic diseases
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