Author: Russell R. A. Kitson

0000000001318090

AUTHOR

Russell R. A. Kitson

showing 2 related works from this author

Synthesis of toxyloxanthone B

2014

A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne, followed by cyclization of the intermediate aryl anion to form the xanthone, the regiochemistry of the aryne addition being confirmed by X-ray crystallography. Subsequent introduction of the pyran ring by [3,3]-rearrangement and deprotection completed the synthesis.

Natural products Xanthones Oxygen heterocycle Benzyne addition Claisen rearrangement.StereochemistryArylOrganic ChemistryRegioselectivitySettore CHIM/06 - Chimica OrganicaRing (chemistry)BiochemistryAryneClaisen rearrangementchemistry.chemical_compoundchemistryPyranDrug DiscoveryXanthone

researchProduct

CCDC 973933: Experimental Crystal Structure Determination

2014

Related Article: Daniele Giallombardo, Adam C. Nevin, William Lewis, Christopher C. Nawrat, Russell R. A. Kitson and Christopher J. Moody|2014|Tetrahedron|70|1283|doi:10.1016/j.tet.2013.12.055

Space GroupCrystallographyCrystal SystemCrystal Structure36-bis(benzyloxy)-17-dihydroxy-9H-xanthen-9-one chloroform solvateCell ParametersExperimental 3D Coordinates

researchProduct

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