0000000001319058

AUTHOR

Elena Lurie-luke

showing 4 related works from this author

Monoamide Derivatives of EDTA Incorporating Pendent Carboxylates or Pyridyls: Synthesis, Metal Binding, and Crystal Structure of a Dinuclear Ca2+ Com…

2017

EDTA is a powerful, cheap and widely-used chelating unit for a large range of metal ions. To link it covalently to other molecules, the formation of an amide bond using one of the carboxylates is an attractive and simple approach, even though it may compromise metal ion binding as one of the four carboxylate donors is lost. Here we undertake a quantitative study of the metal ion binding of two new mono-amide derivatives of EDTA, namely AmGly1 and AmPy1, featuring an additional coordinating carboxylate or pyridyl group in the amide, respectively. The compounds are conveniently synthesised through alkylation of the tris-t-butyl ester of ethylenediamine-triacetic acid with the appropriate α-ch…

inorganic chemicalsAqueous solution010405 organic chemistryStereochemistryChemistryMetal ions in aqueous solutionGeneral ChemistryCrystal structure010402 general chemistry01 natural sciences0104 chemical scienceschemistry.chemical_compoundAmidePolymer chemistryMoleculeChelationCarboxylateCoordination geometryChemistrySelect
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On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis-amide Derivatives of EDTA do not mean Reduced Activity.

2018

EDTA is widely used as an inhibitor of bacterial growth, affecting the uptake and control of metal ions by microorganisms. We describe the synthesis and characterisation of two symmetrical bis-amide derivatives of EDTA, featuring glycyl or pyridyl substituents: AmGly2 and AmPy2 . Metal ion affinities (logK) have been evaluated for a range of metals (Mg2+ , Ca2+ , Fe3+ , Mn2+ , Zn2+ ), revealing less avid binding compared to EDTA. The solid-state structures of AmGly2 and of its Mg2+ complex have been determined crystallographically. The latter shows an unusual 7-coordinate, capped octahedral Mg2+ centre. The antibacterial activities of the two ligands and of EDTA have been evaluated against …

0301 basic medicineStaphylococcus aureusMetal ions in aqueous solution030106 microbiologyBacterial growthmedicine.disease_causeLigandsMedicinal chemistryCatalysisMetal03 medical and health scienceschemistry.chemical_compoundAmidemedicineEscherichia coliEscherichia coliIonsChemistryLigandOrganic ChemistryGeneral ChemistryAmidesAnti-Bacterial Agents030104 developmental biologyMetalsvisual_artvisual_art.visual_art_mediumGrowth inhibitionAntibacterial activityChemistry (Weinheim an der Bergstrasse, Germany)
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CCDC 1508045: Experimental Crystal Structure Determination

2021

Related Article: Raminder S. Mulla, Javier Pitarch-Jarque, Enrique García-España, Tanya Desa, Elena Lurie-Luke, J. A. Gareth Williams|2017|Chem. Sel.|2|5045|doi:10.1002/slct.201700995

hexa-sodium bis(mu-22'-({2-[(carboxylatomethyl){2-[(carboxylatomethyl)amino]-2-oxoethyl}amino]ethyl}azanediyl)diacetato)-diaqua-di-calcium(ii) bis(chloride) hydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1508044: Experimental Crystal Structure Determination

2021

Related Article: Raminder S. Mulla, Javier Pitarch-Jarque, Enrique García-España, Tanya Desa, Elena Lurie-Luke, J. A. Gareth Williams|2017|Chem. Sel.|2|5045|doi:10.1002/slct.201700995

22'-((2-((carboxymethyl)(2-((carboxymethyl)amino)-2-oxoethyl)azaniumyl)ethyl)azaniumyl)diacetateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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