Author: Hélène Bertrand

0000000001319696

AUTHOR

Hélène Bertrand

Recognition of G-quadruplex DNA by triangular star-shaped compounds: with or without side chains?

International audience; We report the synthesis of two new series of triangular aromatic platforms, either with three aminoalkyl side chains (triazatrinaphthylene series, TrisK: six compounds), or without side chains (triazoniatrinaphthylene, TrisQ). The quadruplex-DNA binding behavior of the two series, which differ essentially by the localization of the cationic charges, was evaluated by means of FRET-melting and G4-FID assays. For the trisubstituted triazatrinaphthylenes (TrisK), the length of the substituents and the presence of terminal hydrogen-bond-donor groups (NH(2)) were shown to be crucial for ensuring a high quadruplex affinity (ΔT(1/2) values of up to 20 °C at 1 μM for the best…

research product

CCDC 782553: Experimental Crystal Structure Determination

Related Article: Hélène Bertrand, Anton Granzhan, David Monchaud, Nicolas Saettel, Régis Guillot, Sarah Clifford, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou|2011|Chem.-Eur.J.|17|4529|doi:10.1002/chem.201002810

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
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  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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  - PE11_12Semi-conducting and magnetic materials engineering
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LSLife Sciences
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  - LS4_1Organ and tissue physiology and pathophysiology
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  - LS3_10Developmental genetics
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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SHSocial Sciences and Humanities
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