0000000001319924
AUTHOR
P. Paoli
Compartmentalization of biosynthetic enzymes in bacterial cells: the histidine metabolic pathway case
Introduction: It is known that the inner concentration of proteins within the cell cytoplasm is so high that limits the diffusion of enzymes and metabolic intermediates, leading to a loss of time and energy. Therefore, the organization of genes in operons would have enabled to have enzymes involved in the same metabolic pathway physically close to each other. A corollary to this hypothesis in the possibility of physical interactions between the enzymes of the same metabolic pathway, resulting in the formation of a supramolecular complex capable in channeling the intermediates from one enzyme to a physical adjacent one, with restricted diffusion in the surrounding milieu. Objectives: The aim…
CCDC 136939: Experimental Crystal Structure Determination
Related Article: G.De Munno, M.G.Lombardi, P.Paoli, F.Lloret, M.Julve|1998|Inorg.Chim.Acta|282|252|doi:10.1016/S0020-1693(98)00238-2