0000000001324018
AUTHOR
Angela Aronica
P2‐289: PREVALENCE AND CORRELATES OF SUBJECTIVE MEMORY IMPAIRMENT IN A RURAL ITALIAN POPULATION OF SUBJECTS AGED 50 YEARS AND OVER: DATA FROM THE ZABUT AGING PROJECT
Background: Neuropathology related to dementia slowly accumulates over decades. Consequently, identifying persons at a higher risk of dementia could postpone or prevent dementia by timely targeting modifiable risk factors. In this light, mild cognitive impairment (MCI) has been identified as the transitional stage between normal aging and dementia. So far, the understanding of MCI in thegeneral population remains limited. Therefore,we investigated determinants, MRI-correlates, and prognosis of MCI within the populationbasedRotterdamStudy.Methods:A total of 4198 participants were included in this study. Firstly, we studied age, APOE4 carriership, waist circumference, hypertension, diabetes m…
Vascular risk factors in Alzheimer’s disease and Mild Cognitive Impairment: population data from the Zabùt Aging Project
Background: Alzheimer's disease (AD) is the most common cause of dementia in older adults, accounting for about 60% of cases. However, autopsy studies suggested that mixed dementia, with vascular and neurodegenerative AD pathology, accounts for nearly 20% of dementia cases. Aims: Aim of the present study was to evaluate the relationship between isolated or clustered Vascular Risk Factors (VRFs)/diseases and Mild Cognitive Impairment (MCI) or AD. The study was conducted using a Sicilian population-based cohort dataset collected in low-educated, rural subjects, the Zabùt Aging Project (ZAP). The effect-modification by age, sex, education, genetic factor (APOE4 allele carrier), undernutrition,…
ORAL HEALTH STATUS AND PERIODONTITIS IN ALZHEIMER'S DISEASE:A POPULATION-BASED, CASE-CONTROL STUDY FROM THE ZABUT AGING PROJECT
Aims. The aetiopathogenesis for Alzheimer's disease (AD) have not been defined, although inflammation within the brain is thought to play a role. Recent data suggest that peripheral infections contribute to the inflammatory state of central nervous system diseases, including cognitive impairment and dementia (1). Periodontitis (PD) is a prevalent, chronic infection involving the tissues supporting the teeth associated with gram negative, anaerobic bacteria capable of promoting local and systemic release of inflammatory mediators. Aim of the present study was to assess the oral health status and the prevalence/severity of PD in incident AD subjects evaluated during a population-based, 10-yea…
Erratum: FragClust and TestClust, two informatics tools for chemical structure hierarchical clustering analysis applied to lipidomics. The example of Alzheimer's disease (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-015-9229-6)
Erratum to: FragClust and TestClust, two informatics tools for chemical structure hierarchical clustering analysis applied to lipidomics. The example of Alzheimer’s disease
FragClust and TestClust, two informatics tools for chemical structure hierarchical clustering analysis applied to lipidomics. The example of Alzheimer's disease
Lipidomic analysis is able to measure simultaneously thousands of compounds belonging to a few lipid classes. In each lipid class, compounds differ only by the acyl radical, ranging between C10:0 (capric acid) and C24:0 (lignoceric acid). Although some metabolites have a peculiar pathological role, more often compounds belonging to a single lipid class exert the same biological effect. Here, we present a lipidomics workflow that extracts the tandem mass spectrometry data from individual files and uses them to group compounds into structurally homogeneous clusters by chemical structure hierarchical clustering analysis (CHCA). The case-to-control peak area ratios of the metabolites are then a…
Analisi di un sistema di raffrescamento passivo integrativo a sistemi tradizionali per una torre residenziale, Palermo
Analisi di un sistema di raffrescamento passivo integrativo a sistemi tradizionali per una torre residenziale, Palermo