0000000001325811
AUTHOR
V. Ricca
Adherence issues related to sublingual immunotherapy as perceived by allergists.
Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered…
Brain histamine depletion enhances motor sequences complexity of mice tested in open field: new insights from temporal pattern analysis
Background: Tourette Syndrome (TS) has been classically related to dopaminergic dysregulation of Basal Ganglia circuitry [1]. However, the identification of a rare autosomal dominant form of TS, linked to a mutation of the key-enzyme for Histamine (HA)1 synthesis (l-Histidine decarboxylase, Hdc), has shed light on a putative involvement of this monoamine on the pathophysiology of tic and related disorders and fostered the development of coherent animal models [2]. Although HA-deficient rodents display markedly increased tic-like stereotypies following amphetamine administration, neither underlying nor predisposing differences in the open field test have been reported in quantitative measure…