0000000001326906
AUTHOR
Laura Chimenti
Repeated Hyperosmolar Exposure Of Bronchial Epithelial Cells: A Model Of Exercise-Induced Airways Damage
Moderately cold weather increases bronchial epithelial cells (BECs) and apoptosis in induced sputum of long-distance runners.
Airway cell composition at rest and after an all-out test in competitive rowers
Med Sci Sports Exerc. 2004 Oct;36(10):1723-9. Airway cell composition at rest and after an all-out test in competitive rowers. Morici G, Bonsignore MR, Zangla D, Riccobono L, Profita M, Bonanno A, Paternò A, Di Giorgi R, Mirabella F, Chimenti L, Benigno A, Vignola AM, Bellia V, Amato G, Bonsignore G. SourceDepartment of Experimental Medicine Italian National Research Council (CNR), Palermo, Italy. Abstract PURPOSES: This study was designed to assess: a) whether rowing affects airway cell composition, and b) the possible relationship between the degree of ventilation during exercise and airway cells. SUBJECTS AND METHODS: In nine young, nonasthmatic competitive rowers (mean age +/- SD: 16.2 …
Endurance training damages small airway epithelium in mice.
RATIONALE: In athletes, airway inflammatory cells were found to be increased in induced sputum or bronchial biopsies. Most data were obtained after exposure to cold and dry air at rest or during exercise. Whether training affects epithelial and inflammatory cells in small airways is unknown. OBJECTIVES: To test whether endurance training under standard environmental conditions causes epithelial damage and inflammation in the small airways of mice. METHODS AND MEASUREMENTS: Formalin-fixed, paraffin-embedded lung sections were obtained in sedentary (n = 14) and endurance-trained (n = 16) Swiss mice at baseline and after 15, 30, and 45 days of training. The following variables were assessed (m…
Effect of cilomilast (Ariflo) on TNF-α, IL-8, and GM-CSF release by airway cells of patients with COPD
Background: Inflammation in chronic obstructive pulmonary disease (COPD) is characterised by increased neutrophilic infiltration of the airways. Cilomilast, a novel selective phosphodiesterase 4 inhibitor in clinical development for COPD treatment, exerts anti-inflammatory effects. The ability of cilomilast to inhibit the release of neutrophil chemoattractants such as tumour necrosis factor (TNF)-α, interleukin (IL)-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) by bronchial epithelial cells and sputum cells isolated from 10 patients with COPD, 14 normal controls, and 10 smokers was investigated. Methods: Bronchial epithelial cells obtained by bronchial brushing and sputum…
Effects of Exercise on the Airways
In the last ten years, the effects of exercise on bronchial epithelial cells and inflammatory cells in the airways have been studied in detail, and such new information has been combined with previous knowledge on bronchial reactivity and asthma evoked by exercise in asthmatic patients and athletes. The resulting picture is very complex, and the potential clinical consequences are often contradictory, suggesting the opportunity to define different phenotypes of exercise-associated airway changes (Lee & Anderson, 1985; Haahtela et al., 2008; Moreira et al., 2011a). Studies in asthmatic athletes in the 90’ had began to explore the possibility that airway inflammation might be involved in exer…
Endurance raining damages small airway epithelium in mice
Low concentrations of inflammatory markers in induced sputum of nonasthmatic athletes at rest and after a running race.
Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise
J Appl Physiol. 2010 Jul;109(1):60-7. Epub 2010 May 6. Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise. Bonsignore MR, Morici G, Riccioni R, Huertas A, Petrucci E, Veca M, Mariani G, Bonanno A, Chimenti L, Gioia M, Palange P, Testa U. SourceBiomedical Department, Internal and Specialistic Medicine (DIBIMIS), Section of Pneumology, University of Palermo, Via Trabucco, 180, 90146 Palermo, Italy. marisa@ibim.cnr.it Abstract The effects of endurance or maximal exercise on mobilization of bone marrow-derived hemopoietic and angiogenetic progenitors in healthy subjects are poorly defined. In 10 healthy amateur runners, we collect…
Increased markers of angiogenesis in peripheral blood in long distance runners after a race
Plasma leptin and VEGF levels after maximal exercise at high altitude (5050 m)
Beneficial effects of low intensity endurance training in adult mdx mise
Time couse of changes in airway cells during early training in healthy subjects
Environmental conditions, air pollutants, and airway cells in runners: a longitudinal field study
Runners have increased numbers of neutrophils in the airways at rest and after exercise compared with sedentary individuals. The aim of this study was to determine whether Mediterranean seasonal changes in temperature, humidity or airborne pollutants affect the airway cells of runners training outdoors in an urban environment. In nine male amateur runners, cell composition, apoptosis, and inflammatory mediators were measured in induced sputum collected at rest (baseline) and the morning after races held in the fall (21 km), winter (12 km), and summer (10 km). Concentrations of air pollutants were below the alert threshold at all times. Neutrophil differential counts tended to increase after…
Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.
Background: Intermittent hypoxia and obesity which are two pathological conditions commonly found in patients with obstructive sleep apnea (OSA), potentially enhance cancer progression. Objective: To investigate whether obesity and/or intermittent hypoxia (IH) mimicking OSA affect tumor growth. Methods: A subcutaneous melanoma was induced in 40 mice [22 obese (40–45 g) and 18 lean (20–25 g)] by injecting 106 B16F10 cells in the flank. Nineteen mice (10 obese/9 lean) were subjected to IH (6 h/day for 17 days). A group of 21 mice (12 obese/9 lean) were kept under normoxia. At day 17, tumors were excised, weighed and processed to quantify necrosis and endothelial expression of vascular endothe…
Effect of maximal exercise on reticulocytes in athletes
Bronchial epithelial thickness is increased in small airways of MDX mise at rest and after training
Endurance training increases inflammatory cells in small airways of mice
Effetti delle variazioni climatiche sulle cellule delll'espettorato indotto in maratoneti amatoriali
Longitudinal Changes and Apoptosis in Induced Sputum Cells in Long-Distance Runners
Release of bone-marrow derived hematopoietic and endothelial progenitors after a marathon race
RELEASE OF HEMOPOIETIC AND ENDOTHELIAL PROGENITORS AFTER ENDURANCE AND MAXIMAL EXERCISE IN RUNNERS
Effects of repeated hyperosmolar exposure on IL-8 release by bronchial epithelial cells
Endurance exercise causes mild bronchial epithelial damage in humans
Functional role of PAR-1 receptors in the epithelial cells of smokers with and without COPD: involvement of intracellular signal pathways.
Variable Release of Interleukin-8 after Hyperosmolar Exposure of Bronchial Epithelial Cell Lines.
Increased bronchial epithelial thickness in small airways of mdx mice at rest and after exercise training
Endurance exercise causes apoptosis of inflammatory cells and no clear inflammatory activation in the airways of endurance athletes
Time course of changes in airway cells during early training in healthy subjects
Increased numbers of inflammatory cells but decreased activation of NFkappaB pathway in small airways of endurance-trained mice.
Effects of exercise training on airway responsiveness and airway cells in healthy subjects.
J Appl Physiol. 2010 Aug;109(2):288-94. Epub 2010 Jun 10. Effects of exercise training on airway responsiveness and airway cells in healthy subjects. Scichilone N, Morici G, Zangla D, Chimenti L, Davì E, Reitano S, Paternò A, Santagata R, Togias A, Bellia V, Bonsignore MR. SourceDept. of Internal Medicine, Div. of Pulmonology (DIBIMIS Univ. of Palermo, "Villa Sofia-Cervello" Hospital, Via Trabucco 180, 90146 Palermo, Italy. n.scichilone@libero.it Abstract Airway responsiveness to methacholine (Mch) in the absence of deep inspirations (DIs) is lower in athletes compared with sedentary individuals. In this prospective study, we tested the hypothesis that a training exercise program reduces th…
Endurance training damages small airway epithelium in mice.
Apoptosis in induced sputum cells in long-distance runners: a longitudinal study.
Increased numbers of inflammatory cells but decreased activation of NFκB pathway in small airways of endurance-trained mice
Mild bronchial epithelial damage after endurance exercise in humans
Effects of hyperosmolar stimulation on IL-8 release in different bronchial epithelial cell lines
Release of bone marrow derivied hemopoietic and endothelial progenitors after a marathon race.
Exercise-induced changes in airway cells
Airway cells after swimming outdoors or in the sea in nonasthmatic athletes
BONSIGNORE, M. R., G. MORICI, L. RICCOBONO, M. PROFITA, A. BONANNO, A. PATERNO, R. DI GIORGI, L. CHIMENTI, P. ABATE, F. MIRABELLA, A. M. VIGNOLA, and G. BONSIGNORE. Airway Cells after Swimming Outdoors or in the Sea in Nonasthmatic Athletes. Med. Sci. Sports Exerc., Vol. 35, No. 7, pp. 1146–1152, 2003. Marathon runners and elite swimmers showed increased inflammatory cells in the airways at baseline. Although airway neutrophils increase further after a marathon race, the airway response to swimming is unknown. The aim of this study was to assess the effects of swimming on airway cells. To avoid the concomitant effects of chronic exposure to chlorine, the study was conducted in seven nonasth…
Repeated stretch and mild hyperosmolarity: a model of exercise-induced activation of bronchial epithelial cells.
MILD BRONCHIAL EPITELIAL DAMANGE AFTER ENDURANCE EXERCISE IN HUMANS
Early effects of training on airway cell composition in healthy subjects
Endurance Exercise Causes Mild Bronchial Epithelial Damage in Humans.
OZONE EXPOSURE INCREASES EXERCISE-INDUCED PULMONARY DAMAGE AND INFLAMMATION IN NONASTHMATIC LONG-DISTANCE RUNNERS
Functional role of PAR-1 receptors in the epithelial cells of smokers with and without COPD: involvement of intracellular pathway
Remodeling and inflammation of small airways in endurance trained mice
Effect of endurance and maximal exercise on reticulocytes in athletes
Hyperosmolar exposure of different bronchial epithelial cell lines induces variable release of interleukin-8
Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners.
Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L857-62. Epub 2010 Apr 2. Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners. Chimenti L, Morici G, Paternò A, Santagata R, Bonanno A, Profita M, Riccobono L, Bellia V, Bonsignore MR. SourceDept. Biomedico Di Medicina Interna & Specialistica, Section of Pneumology, Univ. of Palermo, Via Trabucco 180, 90146 Palermo, Italy. laurachimenti@yahoo.it Abstract High neutrophil counts in induced sputum have been found in nonasthmatic amateur runners at rest and after a marathon, but the pathogenesis of airway neutrophilia in athletes is still poorly understood. Bronchial epithelial damage may occur during intense exer…