Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone

none 25 no Abstract OBJECTIVES: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. METHODS: We performed a multicenter retrospective cohort study of patients treated with MTX in MS centers under the Italian national health care system between 1998 and 2008. Demographic, disease, treatment, and follow-up information were collected using hospital records. RESULTS: Data were available for 3,220 patients (63% women) from 40 Italian centers. Follow-up (mean ± SD) was 49 ± 29 months (range 12-140 months). We observed 30 cases of AML (incidence 0.93% [95% confidence interval 0.60%…

A customized dental CT software for automatic correction of patient positioning error and detection of jaw midline

Bartotraumatic Blowout Fracture After Sneezing: Cone Beam CT demonstration

Rarely a blowout orbital fracture is related to sneezing in patients with no history of trauma or sinus surgery. A case of barotraumatic, pure and isolated blowout fracture of the right orbit after sneezing diagnosed by CBCT is reported. A forty-year-old man complained sudden right diplopia after vigorous sneezing. On MRI a reduced size and an altered shape of the right maxillary sinus, a slightly increased vertical diameter of the right orbit, a round shape of the inferior rectus muscle on coronal sections, and a right maxillary haemosinus were observed. A strong peripheral enhancement of the maxillary sinus wall was evident. One week after the patient was submitted to a maxillofacial CBCT…

CBCT in the detection of odontoma

OBJECTIVES: Odontoma is the most common among odontogenic tumors, representing 22- 23.9% of them. Impaction, aplasia, malformation, malpositioning, and devitalization of adjacent teeth are associated with 50-70% of odontomas. Two types of odontoma are distinguished, compound and complex. The typical features of compound odontoma are separate, rudimentary, closely positioned toothlike structures . When such buds form an amorphous and irregular conglomerate of dental tissue without a clear division, they are classified as complex odontoma. Both types are recognized more frequently in the permanent dentition, typically in the second or third decade of life. The anterior maxilla and the posteri…