Effects of Beclomethasone dipropionate and Formoterol in reducing oxidative stress induced by cigarette smoke extracts and IL-17

2011

Rationale: Oxidative stress is involved in airway inflammatory diseases. Inhaled-corticosteroids reduce airway inflammation and the combination with long-acting β2 agonists enhances this effect. Objective: to investigate whether Cigarette smoke extracts (CSE) and Interleukin-17A (IL-17A) activate airway epithelial cells to release markers of oxidative/nitrosative stress and to investigate the effect of beclomethasone dipropionate (BDP) and formoterol. Methods: Human bronchial epithelial cells (16HBE) were stimulated with different concentrations of CSE (from 0 to 10%) to evaluate the expression of IL-17 receptor (IL-17R). 16HBE were also stimulated with CSE (2.5%) with and withouth rhIL-17A…