Role of non cholinergic system components in Chronic Rhinosinusitis and Nasal Polyps

2010

The Choline acetyltransferase (ChAT) enzyme and its product Acetylcholine (ACh) are classically components of the cholinergic system, however recent data clearly demonstrated their potential role in the bronchial airway inflammation. The aim of this study was to identify whether ChAT, Muscarinic receptor M3 and ACh are involved in the nasal airway inflammation of subjects with Chronic Rhinosinusitis (CR) and Nasal polyps (common in many patients with CR). We collected nasal specimens from normal subjects, from allergic patients with CR (ACR) and from ACR and nasal polyps. Fragments from surgical biopsies were extracted for both total mRNA and total proteins to analyse the levels of ChAT and…