6533b7cefe1ef96bd1256e40

RESEARCH PRODUCT

Selective favorskii rearrangement in macrocyclic rings

Manuel ArnóEliseo SeoaneJosé R. PedroAntonio Abad

subject

ChemistryStereochemistryOrganic ChemistryDrug DiscoveryFavorskii rearrangementBiochemistry

description

Abstract A mixture of 2,2-dibromo-12-chlorocyclododecanone (IIa) and 2,12-dibromo-2-chlorocyclododecanone (IIb) by Favorskii rearrangement gave selectively methyl 2-chloro-1-cycloundecene-1-carboxylate (IIIa).

https://doi.org/10.1016/s0040-4039(01)90425-3