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RESEARCH PRODUCT
Influence of negative allosteric cooperativity in cation transport.
Ana M. CosteroSantiago Rodriguezsubject
chemistry.chemical_classificationbiologyChemistryATPaseSodiumOrganic ChemistryAllosteric regulationInorganic chemistryIonophorechemistry.chemical_elementCooperativityBiochemistryCrystallographyMembraneDrug Discoverybiology.proteinCrown etherCation transportdescription
Abstract The bis-macrocyclic ether5 seems to have a negative allosteric cooperativity and is able to transport double the amount of Na+ and K+ cations as monocyclic systems. This compound could be used as a simple model of the plasma membrane Na+−K+ ATPase which actively pumps Na+ out and K+ into the cell, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Tetrahedron Letters |