6533b7cefe1ef96bd1256f39
RESEARCH PRODUCT
Catalytic enantioselective Friedel–Crafts alkylation at the 2-position of indole with simple enones
Gonzalo BlayIsabel FernándezCarlos VilaJosé R. Pedrosubject
Indole testZirconiumChemistryOrganic ChemistryDrug DiscoveryEnantioselective synthesisOrganic chemistrychemistry.chemical_elementAlkylationBiochemistryBenzoquinoneFriedel–Crafts reactionCatalysisdescription
Abstract A procedure for the enantioselective alkylation of indole at the 2-position with simple non-chelating enones is described for the first time. Reaction between 4,7-dihydroindole and enones in the presence of zirconium(IV)–BINOL complexes, followed by a p -benzoquinone oxidation gives indoles alkylated at the 2-position with good yields and moderate enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-09-01 | Tetrahedron Letters |