6533b7cefe1ef96bd1256f73
RESEARCH PRODUCT
Tenascin in denervated human muscle
Hans H. GoebelBenedikt Schosersubject
chemistry.chemical_classificationMuscle tissueDenervationendocrine systemPathologymedicine.medical_specialtyanimal structuresbiologymedicine.drug_classTenascinmusculoskeletal systemMonoclonal antibodyExtracellular matrixmedicine.anatomical_structureNeurologychemistryInterstitial spaceembryonic structuresmedicinebiology.proteinImmunohistochemistryNeurology (clinical)Glycoproteindescription
Tenascin is a large oligomeric glycoprotein of the extracellular matrix. Its location is limited in innervated muscle tissues. We investigated immunohistologically, using two monoclonal antibodies (mab) against Tenascin, biopsied denervated human muscle of children and adults. Tenascin was present in the interstitial space among denervated muscle fibres. Accumulation of Tenascin in denervated adult muscle tissue was frequent, accumulation in denervated muscle tissue of children was sparse and weak. The two antibodies reacted correspondingly. Tenascin was not only found in the vicinity of atrophic muscle fibres, but also close to normally sized fibres, suggesting an early stage of denervation even before reduction of muscle fibre volume.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-08-01 | Journal of the Neurological Sciences |