6533b7cefe1ef96bd1256fbe
RESEARCH PRODUCT
New bronchodilators selected by molecular topology.
Julio CortijoJorge GalvezI. Rı́os-santamarinaRamón García-domenechPedro Santamarı́aEsteban J. Morcillosubject
Malemedicine.drug_classStereochemistryAnthrarobinMuscle RelaxationClinical BiochemistryGuinea PigsPharmaceutical ScienceIn Vitro TechniquesBiochemistryMedicinal chemistrychemistry.chemical_compoundStructure-Activity RelationshipBronchodilatorDrug DiscoverymedicineAnimalsTheophyllineMolecular BiologyAcenocoumarolChemistryOrganic ChemistryDiscriminant AnalysisGriseofulvinBronchodilator AgentsTracheaMuscle relaxationBronchodilator AgentsMolecular MedicineFemaleMolecular topologymedicine.drugdescription
Molecular topology has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9 -one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69, and 74%, respectively. Theophylline shows a correspondent value of 77% (Emax = 100% at 1 mM).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-03-01 | Bioorganicmedicinal chemistry letters |