Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives

6533b7cefe1ef96bd1257098

RESEARCH PRODUCT

Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives

Fabiana Plescia Vincenza Maria Catena Cutuli Benedetta Maggio Demetrio Raffa Antonina Caruso Nunzio Guido Mangano Giuseppe Daidone

subject

Male Stereochemistry Analgesic Anti-Inflammatory Agents Pharmaceutical Science Chemical synthesis Rats Sprague-Dawley Mice Structure-Activity Relationship chemistry.chemical_compound Acetic acid Drug Discovery Phenylbutazone medicine Animals Stomach Ulcer Nuclear Magnetic Resonance Biomolecular Analgesics Behavior Animal Bicyclic molecule Acute toxicity Rats chemistry Toxicity Quinazolines Lactam medicine.drug

description

Several new 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.

year	journal	country	edition	language
1999-03-01	Archiv der Pharmazie

https://doi.org/10.1002/(sici)1521-4184(19993)332:2<50::aid-ardp50>3.0.co;2-s

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