6533b7cefe1ef96bd12579ba
RESEARCH PRODUCT
Oxidative halogenation of substituted pyrroles with Cu(II). PartIII. Bromination and chlorination of 2-benzoylpyrrole
S. CaronnaSalvatore Petrusosubject
chemistry.chemical_classificationKetoneChemistryOrganic ChemistryHalogenationchemistry.chemical_elementOxidative phosphorylationMedicinal chemistryChlorideCopperchemistry.chemical_compoundBromidePhase (matter)medicineOrganic chemistryAcetonitrilemedicine.drugdescription
The bromination of 2-benzoylpyrrole with copper(II) bromide in the homogeneous and the heterogeneous phase is described, giving 4- and 5-monobromo derivatives whose ratio decreases as the temperature is increased. The same reaction with copper(II) chloride in acetonitrile at 60° produces 5-chloro-2-benzoylpyrrole as the major product. 4,5-Dihalopyrroles in good yields are obtained with an excess of halogenating agent.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 | Journal of Heterocyclic Chemistry |