6533b7cffe1ef96bd1257c5f
RESEARCH PRODUCT
Primary in vivo T cell reactivity of NZB grafts in H-2 identical allogenic hosts.
U. BotzenhardtJ. MüllerV. SiegmundJ. Siegmundsubject
T-LymphocytesImmunologychemical and pharmacologic phenomenaAutoimmune responsesBiologySerologyAutoimmune DiseasesMinor Lymphocyte Stimulatory AntigensGraft vs Host ReactionMiceIn vivoImmunology and AllergyAnimalsLymphocytesMice Inbred BALB CMice Inbred NZBH-2 AntigensT cell reactivityHematologyOrgan SizeIn vitroTransplantationMice Inbred C57BLKineticsLiverMice Inbred DBALymphocyte TransfusionImmunologyPopliteal Lymph NodeSpleendescription
By means of the Simonson GVH-assay and the popliteal lymph node (PLN) assay, the T-cell reactivity of NZB mice against H-2 identical allogenic cells was investigated in vivo and compared to that of normal mice. None of the normal mice did react, but a highly significant NZB response could be demonstrated, which did not depend on differences in Mls antigens. These in vivo results extend previous findings of a T-cell hyperreactivity of NZB mice in primary in vitro reactions. They favour the possibility that the T-cell hyperreactivity might be relevant in vivo in facilitating autoimmune responses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-07-01 | Immunobiology |