Haloperidola un mildronāta efekti uz žurku apmācību Barnes labirinta testā

6533b7cffe1ef96bd1257ea5

RESEARCH PRODUCT

Haloperidola un mildronāta efekti uz žurku apmācību Barnes labirinta testā

Ingrīda Māgure

subject

description

Atmiņa ir process, kas balstās uz jūtīgām sinaptiskām modifikācijām smadzeņu apgabalos. Atmiņu var pasliktināt dažādas saslimšanas, tai skaitā šizofrēnija, vielas, ko izmanto tās ārstēšanai, piemēram, antipsihotiskais līdzeklis haloperidols. Tādēļ aktuāli ir meklēt jaunas nootropās vielas, kuras novērstu radušos atmiņas traucējumus. Iespējams, mildronāts, kam piemīt kognīciju uzlabojošas īpašības, spētu novērst šos bojājumus. Šajā darbā tika pētīti haloperidola (1 mg/kg) un mildronāta (50 un 100 mg/kg) efekti, pēc 3 nedēļu vielu ievadīšanas, uz žurku telpisko atmiņu Barnes labirinta testā. Rezultāti liecina, ka haloperidola iedarbība pasliktina apmācības procesu un rada atmiņas traucējumus. Mildronāts abās testētajās devās apmācības 4. dienā uzlabo haloperidola izraisītos traucējumus, taču testa jeb atmiņas pārbaudes dienā to neietekmē.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/24376

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