6533b7cffe1ef96bd125829f

RESEARCH PRODUCT

Flow injection-chemiluminescence determination of octyl dimethyl PABA in sunscreen formulations

Alberto ChisvertAmparo SalvadorR.a WheatleyAlan Townshend

subject

Detection limitChromatographyChemistryExcipientSulfuric acidBiochemistryAnalytical Chemistrylaw.inventionchemistry.chemical_compoundPotassium permanganatelawmedicineOCTYL DIMETHYL PABAEnvironmental ChemistrySpectroscopymedicine.drugChemiluminescence

description

Abstract A sensitive flow injection (FI) procedure was developed for the determination of the UV-filter octyl dimethyl PABA in sunscreen formulations based on its chemiluminescence (CL) induced by potassium permanganate in sulfuric acid. Both second-order and log–log calibration graphs can be used to perform the analysis. Ninety injections per hour can be carried out, which means a sample throughput of 18 h −1 if five injections per solution are performed. The limit of detection (3 σ ) was 25 ng ml −1 . The interference effects of the excipient and other UV filters are studied. Sunscreen formulations containing octyl dimethyl PABA were analysed by both the proposed FI-CL method and a liquid chromatography reference method. The two methods gave comparable results.

yearjournalcountryeditionlanguage
2002-07-01Analytica Chimica Acta
https://doi.org/10.1016/s0003-2670(02)00342-2