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RESEARCH PRODUCT

Drug release from calcium and zinc pectinate beads: Impact of dissolution medium composition

Philippe CayotAli AssifaouiOdile Chambin

subject

Polymers and PlasticsOrganic ChemistryInorganic chemistrychemistry.chemical_elementZincCalciumPhosphateDosage formchemistry.chemical_compoundchemistryIonic strengthDrug deliveryMaterials ChemistrymedicineSwellingmedicine.symptomDrug carrierNuclear chemistry

description

The aim of this study was to investigate drug release from calcium and zinc pectinate beads and to understand the impact of medium electrolytes during drug transfer. A potential drug carrier for colonic drug delivery (rutin) was prepared with calcium and zinc pectinate beads and was tested in three different simulated intestinal fluids (pH 7.3) with phosphates (Sorensen’s and Mc Ilvaine’s buffers) and without phosphates (Tris-buffer). According to swelling studies and zinc ions release, it was showed that zinc ions keep adhering to the bead surface. Drug release and swelling behaviour from the two dosage forms depend not only on pH and ionic strength but also on the electrolytes there were in the dissolution medium. In calcium pectinate beads, rutin release was faster when phosphate buffers were used because precipitates (CaHPO4) were formed. This precipitate has a pumping effect on the calcium ions, destabilizing the gel

yearjournalcountryeditionlanguage
2011-05-01Carbohydrate Polymers
https://doi.org/10.1016/j.carbpol.2011.02.037