6533b7cffe1ef96bd1258d47
RESEARCH PRODUCT
Enediolates and dienediolates of carboxylic acids in synthesis. Synthesis of β,γ-epoxyacids from α-chloroketones
Félix VillarEva M. BrunSalvador GilMargarita ParraRamon Mestressubject
Allylic rearrangementChemistryStereochemistryOrganic ChemistryDrug Discoverychemistry.chemical_elementLithiumBiochemistryCombinatorial chemistrydescription
Abstract Lithium dienolates of saturated or α,β-unsaturated acids react with α-chloroketones provide a convenient method for preparation of highly sustituted β,γ-epoxyacids. These highly reactive compounds lead in most cases to variable ammounts of the corresponding β-lactones and allylic alcohols.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-02-01 | Tetrahedron Letters |