6533b7cffe1ef96bd1258e5f
RESEARCH PRODUCT
Effect of Chlorotriphenyl Derivatives of Sn and Pb upon Biophysical Properties of Membranes
Ewa BoniewskaDariusz ManMarian PodolakGrzegorz Engelsubject
Triphenyltin chlorideTime FactorsArticle SubjectCell SurvivalHealth Toxicology and Mutagenesislcsh:BiotechnologySaccharomyces cerevisiaelcsh:MedicineSaccharomyces cerevisiaelcsh:Chemical technologylcsh:TechnologyBiophysical PhenomenaMembrane PotentialsCell membranechemistry.chemical_compoundlcsh:TP248.13-248.65GeneticsmedicineOrganometallic CompoundsOrganotin Compoundslcsh:TP1-1185Molecular BiologyLiposomebiologyChemistrylcsh:TBilayerCell Membranelcsh:RElectron Spin Resonance SpectroscopyLauric AcidsGeneral Medicinebiology.organism_classificationLauric acidYeastMembranemedicine.anatomical_structureBiochemistryLiposomesBiophysicsMolecular MedicineBiotechnologyResearch Articledescription
Biophysical activity of two twin organometallic compounds Triphenyltin chloride (TPhT) and Triphenyllead chloride (TPhL) in their interreaction with model membranes, as well as with yeast cellsSaccharomyces cerevisiae, was investigated. Four measurement methods were used in the experiments: two physical methods (spin probes method and the electric method); two biological methods (minimal inhibitory concentration /MIC/ and yeast survival test). It has been found that the activity of TPhT in interaction with model membranes and yeast cells is distinctly greater than that of TPhL. The activity manifests itself by considerable increase in the fluidity of the middle part of liposome bilayer, change in the polarization direction of the transmembrane voltage of filters impregnated with lauric acid, and in complete inhibition of growth of yeast cells at the concentration of 5 .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-07-01 | Journal of Biomedicine and Biotechnology |