6533b7cffe1ef96bd1258f9d

RESEARCH PRODUCT

TAP off - tumors on

Markus MaeurerMarkus MaeurerSoldano FerroneSoldano FerroneBarbara SeligerBarbara Seliger

subject

Antigen processingImmunologyAntigen presentationCD1Human leukocyte antigenBiologyMHC restrictionMajor histocompatibility complexMajor Histocompatibility ComplexAntigenATP Binding Cassette Transporter Subfamily B Member 3NeoplasmsMHC class IImmunologyTumor Cells Culturedbiology.proteinHumansATP-Binding Cassette TransportersATP Binding Cassette Transporter Subfamily B Member 2

description

Abstract The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.

yearjournalcountryeditionlanguage
1997-06-01Immunology Today
https://doi.org/10.1016/s0167-5699(97)01052-9