6533b7cffe1ef96bd12596f7
RESEARCH PRODUCT
Surface functionalization and surface recognition: Plasmon optical detection of molecular recognition at self assembled monolayers
Jianling YangLukas HäußlingFranz-josef SchmittHelmut RingsdorfWolfgang Prof Dr Knollsubject
StreptavidinPolymers and PlasticsChemistryOrganic ChemistrySelf-assembled monolayerCondensed Matter PhysicsCombinatorial chemistrychemistry.chemical_compoundMolecular recognitionChemisorptionMonolayerMaterials ChemistryOrganic chemistrySurface modificationSelf-assemblyPlasmondescription
The synthesis of biotin- functionalized organic mercaptans and their chemisorption on gold surfaces is described. Biotin bound covalently to self assembled monolayers is recognized by streptavidin from aqueous buffer solutions. Spacer length and packing density of the biotin labels on the organic surface determine the docking kinetics. With a flexible and hydrophilic spacer very fast -diffusion controlled-docking is observed. As an alternative method of self assembly the spreading of organic mercaptans on water surfaces is established. Pressure-area diagrams of different functionalized mercaptans and disulfides are shown and their monolayer properties are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-06-01 | Makromolekulare Chemie. Macromolecular Symposia |