6533b7cffe1ef96bd1259750

RESEARCH PRODUCT

Studies on (echinodermata) coelomocyte lysate I. Hemolytic activity of coelomocyte hemolysins

Donatella CiullaCalogero Canicattì

subject

LysisbiologyImmunologyHemolysinbiology.organism_classificationRed blood cellmedicine.anatomical_structureLytic cycleBiochemistryCell surface receptorImmunologymedicineHolothuriaSphingomyelinCoelomocyteDevelopmental Biology

description

Abstract The Holothuria polii coelomocyte lysate contains two trypsin-resistant lytic proteins having different chemico-physical properties : a calcium dependent and heat-labile hemolysin that is probably a constitutive component of the coelomic fluid, and another calcium independent and heat-stable one that is released after immunological stimulation; it is therefore not detectable in natural conditions. The sphingomyelin seems to be the membrane receptor with which both hemolysins interact producing lysis.

https://doi.org/10.1016/0145-305x(87)90058-9