6533b7cffe1ef96bd1259776

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of Pyrido(2,3-d)pyrimidinones by the Reaction of Aminopyrimidin-4-ones with Benzylidene Meldrum′s Acid Derivatives.

Angelina HormazaNorbert HanoldJairo QuirogaAdolfo SánchezBraulio InsuastyHerbert MeierManuel Nogueras

subject

Nitrobenzenechemistry.chemical_compoundPyrimidinoneschemistryOrganic chemistryGeneral MedicineMeldrum's acid

description

A series of pyrido[2,3-d]pyrimidine-4,7-diones 5a-h were prepared from 6-amino-4-pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and 2 in the addition step.

https://doi.org/10.1002/chin.199738201