6533b7cffe1ef96bd1259776
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Pyrido(2,3-d)pyrimidinones by the Reaction of Aminopyrimidin-4-ones with Benzylidene Meldrum′s Acid Derivatives.
Angelina HormazaNorbert HanoldJairo QuirogaAdolfo SánchezBraulio InsuastyHerbert MeierManuel Noguerassubject
Nitrobenzenechemistry.chemical_compoundPyrimidinoneschemistryOrganic chemistryGeneral MedicineMeldrum's aciddescription
A series of pyrido[2,3-d]pyrimidine-4,7-diones 5a-h were prepared from 6-amino-4-pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and 2 in the addition step.
year | journal | country | edition | language |
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2010-08-03 | ChemInform |