6533b7cffe1ef96bd12597a5
RESEARCH PRODUCT
Les lymphocytes Th9
Frédérique VégranLionel ApetohFrançois MartinFrançois Ghiringhellisubject
0301 basic medicineTumor microenvironmentmedicine.medical_treatmentGeneral MedicineImmunotherapyBiologyGeneral Biochemistry Genetics and Molecular Biology3. Good healthCell biology03 medical and health sciences030104 developmental biology0302 clinical medicineImmune systemmedicineCytotoxic T cellCytokine secretionSecretionInterleukin 9Signal transduction030215 immunologydescription
Th9 cells are CD4 T helper cells characterized by their ability to produce IL-9 and IL-21. These cells are obtained from naive CD4(+) T cells cultured in the presence of TGF-β and IL-4. Thus their differentiation results from the balance between the signaling pathways induced by IL-4 in one hand and the one induced by TGF-β in the other hand. These cells are inflammatory cells and were first described in the context of atopic and autoimmune diseases in which they have a pathogenic role. They are also involved in the defense against parasite infections. Recently, some reports defined Th9 anticancer properties through their cytokine secretion. Indeed, their high secretion of IL-9 and IL-21 in the tumor bed contributes to their anticancer functions. These cytokines trigger the activation of dendritic cells, mast cells, natural killer cells, and CD8 T cells to mount an antitumor immune response.
year | journal | country | edition | language |
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2016-04-01 | médecine/sciences |