mecA gēna noteikšana klīniskajos Staphylococcus aureus celmos

6533b7d0fe1ef96bd1259dc1

RESEARCH PRODUCT

mecA gēna noteikšana klīniskajos Staphylococcus aureus celmos

Katrīna Gruzinska

subject

meticilīnrezistence Staphylococcus aureus mecA gēns nozokomiālās infekcijas Farmācija

description

Staphylococcus aureus ir viens no galvenajiem nozokomiālo infekciju izraisītājiem daudzās attīstītās pasaules valstīs. S.aureus samērā bieži ir meticilīnrezistents, tas nozīmē, ka tam ir rezistence pret visiem klasiskajiem beta laktāmu antibakteriālajiem līdzekļiem. Meticilīnrezistenci nosaka mecA gēns un tā integrācija baktērijas genomā. Baktēriju rezistences pieauguma dēļ būtiski ir noteikt atbilstošu antibakteriālo līdzekļu terapiju efektīvai ārstēšanai. Darba mērķis ir mecA gēna noteikšana klīniskajos Staphylococcus aureus celmos, kas iegūti no pacientiem, kuri ir ilgstoši uzturējušies veselības aprūpes iestādēs. Darbā tika izmantots GenoType® Staphylococcus tests, lai varētu noteikt mecA gēna klātbūtni 24 S.aureus paraugos. Pētījuma rezultāti norāda, ka no 338 S.aureus paraugiem 14 (4%) bija MRSA, tādējādi tika apstiprināta fenotipiski noteiktā rezistence pret cefoksitīnu (meticilīnu).

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/35822

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