6533b7d0fe1ef96bd125a18a
RESEARCH PRODUCT
New potentially cytotoxic thiolatogold(I) complexes of 1,1′-bis(diphenylphosphino)ferrocene
Lyudmila G. KuzminaIlya E. Nifant'evBernard GautheronManuella Viottesubject
StereochemistryHuman bladderChlorine atomMedicinal chemistryInorganic Chemistrychemistry.chemical_compoundFerrocenechemistryColon carcinomaMaterials Chemistry11'-Bis(diphenylphosphino)ferrocenePhysical and Theoretical ChemistryBifunctionalMonoclinic crystal systemdescription
Abstract 1,1′-Bis[chlorogold(I) diphenylphosphino] ferrocene (1) was chosen as the starting material to synthesize new thiolato gold(I) complexes. This has been achieved by substituting the chlorine atoms by monofunctional and bifunctional thiolates affording ‘open’ thiolatogold complexes and trimetallic ferrocenophane-type structures, respectively. The new 1,1′-bis(2,6-dithia-1-phosphanyl)ferrocene (7) containing directly linked P and S atoms was also prepared but no gold complex was obtained. Compound 2 crystallizes in the monoclinic space group P21/n with a=10.2632), b=21.064(4), c=16.259(3) A , β=97.06(2)° and V=3.488(1) A 3 . The distance between the two gold atoms (3.06 A) indicates a significant contact interaction. Compounds 2–5 have allowed antitumoral efficiency on human bladder and colon carcinoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-12-01 | Inorganica Chimica Acta |