Organocatalytic enantioselective Strecker reaction with seven-membered cyclic imines

6533b7d0fe1ef96bd125a40e

RESEARCH PRODUCT

Organocatalytic enantioselective Strecker reaction with seven-membered cyclic imines

Gonzalo Blay Carles Lluna-galán José R. Pedro M. Carmen Muñoz Carlos Vila Isabel Fernández

subject

010405 organic chemistry Chemistry Organocatalysis Dibenzo[b f][1 4]oxazepines Strecker amino acid synthesis Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Reaccions químiques Alpha-amino nitriles Catàlisi Strecker reaction Organocatalysis FISICA APLICADA Asymmetric catalysis Economic history media_common.cataloged_instance European union media_common

description

[EN] A highly enantioselective Strecker reaction with dibenzo[b,f][1,4]oxazepines has been described using a dihydroquinine-derived thiourea as organocatalyst. The reaction affords chiral 10,11-dihydrodibenzo[b,f][1,4] oxazepine 11-carbonitrile derivatives in excellent yields (up to 99%) and excellent enantioselectivities (up to 98%) under mild reaction conditions.

year	journal	country	edition	language
2018-08-09

10.1002/adsc.201800754 https://hdl.handle.net/10550/73682

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