6533b7d0fe1ef96bd125a52e

RESEARCH PRODUCT

Regional cerebral blood flow and regional metabolism in cold induced oedema.

subject

description

24 hours following a cold induced oedema in cats rCBF was measured in the lesion area, the bluish stained cortex immediately adjacent to the lesion, a cortical area remote from the lesion, and in the contralateral uninjured hemisphere. Thereafter the brain was frozen and the respective tissue areas were removed and analyzed for water and electrolyte content as well as metabolite concentrations. It seems, that in the neighbourhood of a local lesion at least 3 different brain regions can be differentiated with regard to their characteristic pattern of data. In non-oedematous regions either hyperaemia or hypoaemia could be observed. In areas with local brain oedema rCBF was reduced inversely proportional to the tissue water content. It seems that the “luxury perfusion syndrome” represents only one of several possibilities of regional flow pattern around a local brain lesion and its occurrence is confined to non-oedematous areas. Reduction of rCBF by 20% in the remote and by 33% in the adjacent oedematous areas does not cause significant changes in the tissue concentrations of phosphocreatine, ATP and ADP, while lactate and the L/P ratio are clearly elevated. A significant drop of the high-energy compounds is found in the lesion, where the flow was reduced by about 62%. This indicates that the local tissue hypoxia occurs as a result of the diminution in local microcirculation.