6533b7d0fe1ef96bd125a54f
RESEARCH PRODUCT
Convergent synthesis and preliminary biological evaluations of the stilbenolignan (±)-aiphanol and various congeners
G. Paul SavageAnna BezosSatish ChandHolger UlbrichChristopher R. ParishGerd DannhardtWerner KieferMartin G. BanwellUlrike Nowesubject
Magnetic Resonance SpectroscopyConvergent synthesisAngiogenesis InhibitorsBiochemistryInhibitory Concentration 50chemistry.chemical_compoundStilbenesAnimalsOrganic chemistryBioassayCyclooxygenase InhibitorsPhysical and Theoretical ChemistryBenzeneAortaSilver carbonateCyclooxygenase 2 InhibitorsDose-Response Relationship DrugCinnamyl alcoholChemistryOrganic ChemistryMembrane ProteinsStereoisomerismRatsIsoenzymesEnzyme inhibitionCyclooxygenase 2Prostaglandin-Endoperoxide SynthasesCyclooxygenase 1description
Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone–benzene afforded a ca. 2 : 1 : 2 : 1 mixture of the stilbenolignan (±)-aiphanol (1) and congeners 2–4 each of which show significant anti-angiogenic and COX-2 inhibitory properties.
year | journal | country | edition | language |
---|---|---|---|---|
2003-09-06 | Org. Biomol. Chem. |