6533b7d0fe1ef96bd125abb9

RESEARCH PRODUCT

Cavity ring down spectrometry for disease diagnostics using exhaled air

Atis SkudraGita RevaldeJ. AlnisKarlis Grundsteins

subject

Detection limitMaterials scienceSpectrometerAnalytical chemistrymedicine.disease_causeMass spectrometryLaserlaw.inventionchemistry.chemical_compoundBreath gas analysischemistrylawmedicineCalibrationBenzeneUltraviolet

description

In this paper we report the current stage of the development of a cavity ring-down spectrometer (CRDS) system using exhaled human breath analysis for the diagnostics of different diseases like diabetes and later lung cancer. The portable CRDS system is made in ultraviolet spectral region using Nd:Yag laser 266 nm pulsed light. Calibration of the CRDS system was performed using generated samples by KinTek automated permeation tube system and self-prepared mixtures with known concentration of benzene and acetone in air. First experiments showed that the limits of detection for benzene and acetone are several tens of ppb.

https://doi.org/10.1117/12.2297126