6533b7d0fe1ef96bd125ac5d
RESEARCH PRODUCT
New hydrogel matrices based on chemical crosslinked α,β -polyas parthydrazide: Synthesis, characterization and in vivo biocompatibility studies
Santi SpampinatoGiovanna PitarresiGaetano GiammonaT. CampanaPaolo GovoniVincenzo Tomarchiosubject
Aqueous solutionBiocompatibilityChemistryScanning electron microscopetechnology industry and agriculturePharmaceutical Sciencemacromolecular substancesDosage formchemistry.chemical_compoundChemical engineeringIn vivoPolymer chemistrySelf-healing hydrogelsmedicineGlutaraldehydeSwellingmedicine.symptomdescription
New swellable micromatrices of α,β-polyasparthydrazide (PAHy) crosslinked with glutaraldehyde were prepared. The effect of crosslinking agent concentration was evaluated. In particular, crosslinking density affected aqueous dynamic swelling and glass-transition temperature of the material. The structure of prepared networks was also studied by scanning electron microscopy and X-ray analysis. Finally, biocompatibility of PAHy derivatives was investigated in vivo by subcutaneous implantation and in oral administration to laboratory animals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-02-17 | International Journal of Pharmaceutics |