6533b7d0fe1ef96bd125af1a

RESEARCH PRODUCT

Selective mono-de-O-acetylation of the per-O-acetylated brasilicardin carbohydrate side chain

Michael EitelMichael EitelPierre KochPierre KochDieter SchollmeyerDhafer Saber ZinadHarald Gross

subject

Natural product010405 organic chemistryChemistryOrganic ChemistryCarbohydratesAcetylationGeneral MedicineCarbohydrate010402 general chemistryMolecular sieve01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistrychemistry.chemical_compoundAcetylationSide chainOrganic chemistryMethanolProtein Processing Post-Translational

description

Abstract Methanol dried over powdered 4 A molecular sieves can be used for a selective mono-de-O-acetylation of the phenolic acetyl group of the per-O-acetyl protected brasilicardin A carbohydrate side chain. This reaction opens a practical procedure for a synthetic access to derivates of the immunosuppressive and cytotoxic natural product brasilicardin A.

yearjournalcountryeditionlanguage
2021-06-01Carbohydrate Research
https://doi.org/10.1016/j.carres.2021.108312